pI: 4.5181 |
Length (AA): 357 |
MW (Da): 39391 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 357 | 3fz0 (A) | 2 | 357 | 99.99 | 0 | 1 | 2.1877 | -1.78 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
NA% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127001)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G05620 | inosine nucleoside hydrolase |
Arabidopsis thaliana | AT2G36310 | Uridine nucleosidase 1 |
Candida albicans | CaO19.9444 | uridine ribohydrolase |
Candida albicans | CaO19.1888 | uridine ribohydrolase |
Caenorhabditis elegans | CELE_F13H8.3 | Protein F13H8.3 |
Caenorhabditis elegans | CELE_Y43F8C.13 | Protein Y43F8C.13 |
Dictyostelium discoideum | DDB_G0272738 | N-D-ribosylpurine ribohydrolase |
Drosophila melanogaster | Dmel_CG5418 | CG5418 gene product from transcript CG5418-RA |
Drosophila melanogaster | Dmel_CG12177 | CG12177 gene product from transcript CG12177-RA |
Drosophila melanogaster | Dmel_CG11158 | CG11158 gene product from transcript CG11158-RA |
Escherichia coli | b0651 | ribonucleoside hydrolase 1 |
Escherichia coli | b2162 | ribonucleoside hydrolase 2 |
Escherichia coli | b0030 | ribonucleoside hydrolase 3 |
Entamoeba histolytica | EHI_199960 | Inosine-uridine preferring nucleoside hydrolase, putative |
Giardia lamblia | GL50803_13272 | Hypothetical protein |
Leishmania braziliensis | LbrM.14.0130 | inosine-guanine nucleoside hydrolase, putative |
Leishmania braziliensis | LbrM.18.1610 | nonspecific nucleoside hydrolase;with=GeneDB:LmjF18.1580 |
Leishmania donovani | LdBPK_181570.1 | nonspecific nucleoside hydrolasewith |
Leishmania donovani | LdBPK_140130.1 | nucleoside hydrolase-like protein |
Leishmania infantum | LinJ.18.1570 | nonspecific nucleoside hydrolase;with=GeneDB:LmjF18.1580 |
Leishmania infantum | LinJ.14.0130 | inosine-guanine nucleoside hydrolase, putative |
Leishmania major | LmjF.14.0130 | inosine-guanine nucleoside hydrolase, putative |
Leishmania major | LmjF.18.1580 | nonspecific nucleoside hydrolase |
Leishmania mexicana | LmxM.18.1580 | nonspecific nucleoside hydrolase |
Leishmania mexicana | LmxM.14.0130 | nucleoside hydrolase-like protein |
Mycobacterium tuberculosis | Rv3393 | Probable nucleoside hydrolase IunH (purine nucleosidase) |
Oryza sativa | 4346302 | Os08g0557900 |
Oryza sativa | 4333153 | Os03g0425200 |
Oryza sativa | 4347891 | Os09g0567900 |
Saccharomyces cerevisiae | YDR400W | trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase |
Schmidtea mediterranea | mk4.003175.02 | |
Schmidtea mediterranea | mk4.005381.00 | |
Trypanosoma brucei gambiense | Tbg972.7.5180 | nucleoside hydrolase, putative |
Trypanosoma brucei | Tb927.7.4570 | inosine-guanine nucleoside hydrolase |
Trypanosoma congolense | TcIL3000_7_3810 | nucleoside hydrolase, putative |
Trypanosoma cruzi | TcCLB.506605.170 | inosine-guanine nucleoside hydrolase, putative |
Trichomonas vaginalis | TVAG_092730 | inosine-uridine preferring nucleoside hydrolase, putative |
Trichomonas vaginalis | TVAG_424130 | inosine-uridine preferring nucleoside hydrolase, putative |
Trichomonas vaginalis | TVAG_213720 | inosine-uridine preferring nucleoside hydrolase, putative |
Trichomonas vaginalis | TVAG_305790 | inosine-uridine preferring nucleoside hydrolase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.4570 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.4570 this record | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.4570 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.4570 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0030 | Escherichia coli | non-essential | goodall |
b0651 | Escherichia coli | non-essential | goodall |
b2162 | Escherichia coli | non-essential | goodall |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Crithidia fasciculata | Inosine-uridine preferring nucleoside hydrolase | Compounds | References |
Target | Type | Source | Notes |
---|---|---|---|
Tb927.7.4570 | purified protein | BRENDA | A protein with this EC number or name or sequence has been purified from Trypanosoma brucei ( 1 ) |
13 literature references were collected for this gene.